| Generic Name | Trade Names | Pregnancy Category | Pregnancy Notes | Lactation Notes |
|---|
| Acetaminophen | Tylenol™ | B | Compatible | Compatible |
| Ibuprofen | Advil | B | 1st and 3rd trimester risk | Compatible |
| Codeine | in Robitussin AC™ and Tylenol #3 | C | 3rd trimester risk | Limited human data, probably compatible |
| Hydroxyzine | Vistaril | C | Human data suggest low risk | |
| Pyridoxine, Vitamin B6 | | A | Compatible | Compatible, but excessively high doses inhibit lactation |
| Metoclopramide | Reglan | B | Compatible | Unknown effects, limited human data, potential toxicity due to dopaminergic blocking mechanism. However, sometimes given to induce lactation. |
| Promethazine | Phenergan | C | Compatible | No human data, probably compatible |
| Ondansetron | Zofran | B | Limited human data, animal data suggest low risk. | No human data, probably compatible |
| Doxylamine | | A | Compatible | No human data, probably compatible |
| Trimethobenzamide | Tigan | C | Human data suggest low risk | No human data, probably compatible |
| Saline Nasal spray | Ocean™ | A | Safe | Safe |
| | Vick's vapor-rub | | Not ingested, and therefore safe | Safe |
| Steam inhalation | | | Safe | Safe |
| Vaseline | | | applied nasally or on lips, and therefore safe | Safe |
| | NasalCrom™ | B | Compatible | No data, probably compatible |
| | Afrin™ | C | insufficient evidence. Small studies show normal use ok, but heavy use, (against label), results in fetal brady most likely from vasoconstrictor activity. | Compatible |
| | Flonase™ | C | No other data found by me | Unknown, no other data found by me |
| | Nasocort™ | C | No other data found by me regarding nasal administration, but other routes are classified as having risk. | No human data, probably compatible |
| Dextromethorphan | in Robitussin DM | C | Compatible | Compatible |
| Codeine | | See above | | |
| Diphenhydramine | Benadryl | B | Compatible | Limited human data, probably compatible, though antihistamines are suspected to decrease lactation |
| Loratadine | Claritin™ | B | | |
| Cetirizine | Zyrtec™ | B | | |
| Pseudoephedrine | Sudafed™ | C | Limited human data and no relevant animal data, not recommended before 18weeks given association with omphalocele | Limited human data, probably compatible, compatible per AAP, but known to sometimes reduce or halt lactation |
| Phenylephrine | | C | Human data suggest risk | No human data, probably compatible, but known to sometimes reduce or halt lactation |
| Guaifenesin | in Robitussin DM, AC, and Mucinex™ | C | Compatible, Surveillance studies show no increased risks of birth defects | No human data, probably compatible |
| Ranitidine | Zantac | B | Compatible | Limited human data, probably compatible, cimetidine compatible per AAP |
| Pantoprazole | Protonix | B | No human data, animal data suggest low risk | Limited human data with potential toxicity |
| Omeprazole | Prilosec | C | Human data suggest low risk | Limited human data with potential toxicity |
| Fluconazole | Diflucan | C | Human data suggest risk at >=400mg/day 1st trimester especially | Compatible |
| Cephalexin | Keflex | B | Safe | Safe |
| Ciprofloxacin | | C | Human data suggest risk | Limited human data, probably compatible, compatible per AAP |
| Nitrofurantoin | Macrobid | B | Risk in 3rd trimester of hemolytic anemia possibly from immature erythrocyte enzymes - glutathione. | Limited human data, probably compatible |
| TMP-SMX | Bactrim, Septra | C | Human data suggest risk | Compatible |
| | | | | |